North Carolina was burned for 28 points by Tre Jones on Saturday as Duke picked up a 98-96 win at Dean E. Smith Center.
Bettors who backed Duke were disappointed, as they failed to cover the closing number of -7.5.
Cassius Stanley had 22 points for Duke and Vernon Carey Jr. chipped in with 18 points. Tre Jones had 6 assists for them, while Wendell Moore Jr. was the team's top rebounder, grabbing 10 boards.
North Carolina got a 24-point performance from Cole Anthony, who was supported by 18 points from Garrison Brooks. Leaky Black had 9 assists in a losing cause for North Carolina, while Cole Anthony grabbed 11 rebounds.
Duke was losing at the break before taking care of business in the second half.
North Carolina won the battle of the boards, outrebounding their counterparts 45-40.
Duke heads into a battle against Florida State. North Carolina, meanwhile, will have their next action against Wake Forest.